Citriodiol® has been extensively tested in field and laboratory trials and has passed rigorous safety assessments.

If used according to label instructions, Citriodiol® is not expected to pose a health risk to people, including children and sensitive populations (US EPA) .

Low Toxicity

Beyond acute toxicity assessments, Citriodiol® has been shown to:

  • Have no phototoxic potential
  • Be non-mutagenic
  • Pass the chromosome aberration test
  • Be negative for inducing forward mutations at the TK locus in L5178Y mouse lymphoma cells
  • Be negative in the in-vivo mouse micronucleus assay
  • Have no adverse reproductive or dermal developmental effect.

Low Transdermal Absorption

Compared with other dermally applied actives, very little Citriodiol® is absorbed through the skin and into the bloodstream, minimising the impact on the consumers body.  It is not classified as a skin sensitiser or dermal irritant.  The US CDC however recommends that no insect repellents should be applied under clothing as there may be an increased rate of dermal absorption due to perspiration.

Suitable for Children

Our quantitative human health risk assessment supports application to children from 3 months, however due to reduced epidermis thickness and potentially greater sensitivity in children of this age, Citrefine recommend application from 6 months.  Be aware that age restrictions may vary by country so advise us of your specific requirements and we can provide more tailored advice.

Family and Environmentally Friendly

Learn why Citriodiol® is ‘The Natural Solution

Review our safety and efficacy studies


Suitable for Pregnant and Nursing Women

While we have not conducted studies directly on pregnant women for ethical reasons, data generated from multi-generation toxicity studies, together with the very low rate of dermal absorption of Citriodiol®, supports unrestricted use by pregnant women.  This conclusion was supported by the US EPA when it registered the product more than a decade ago allowing its unrestricted use by pregnant women when used in accordance with the product label.

Citriodiol is the natural solution



Safety data sheets and certificates addressing the following aspects are available:

  • Does not contain GMOs
  • Is not hazardous for transport
  • Is not a carcinogenic, mutagenic or toxic for reproduction (CMR) substance
  • Does not contain nanomaterials
  • Is not classified as a persistent, bioaccumaltive or toxic (PBT)
  • Has no TSE/BSE risk
  • Has no heavy metals

Safe for the Environment

In addition to the many toxicological studies of Citriodiol® to ensure product safety for consumers and stability tests on PCR (post-consumer recycled) plastics, Citrefine has also conducted environmental testing to ensure that its products are not harmful to the environment.

These tests have proven that Citriodiol® is rapidly biodegradable, so will not build up to potentially harmful levels in our soils or waterways, unlike many synthetic alternatives such as DEET. Citriodiol® is sourced from natural GMO-free plant oil, is organic and is not toxic to birds, honey bees and other insects beneficial to the environment.

Citriodiol® has been approved by ECOCERT as a raw material that meet the COSMOS Standards for organic and natural ingredients. As a COSMOS approved ingredient, Citriodiol® can be used in end-use products which are to be certified as COSMOS natural or COSMOS organic.


The guiding principles of COSMOS are to:

          • Promote the use of products from organic agriculture, and respect biodiversity
          • Use natural resources responsibly, and respect the environment
          • Use processing and manufacturing that are clean and respectful of human health and the  environment
          • Integrate and develop the concept of “Green Chemistry”

ECOCERT approval gives customers confidence that Citriodiol® is sourced and manufactured in a way that is totally aligned with the above principles.

The ECOCERT approval is only given to raw materials that meet strict requirements regarding the origin of the material (e.g. not using GMOs, not endangering species) and the material must also meet strict criteria relating to processing of the material (e.g. use of starting materials with strict toxicity and biodegradability limits).

US Consumer Report shows Citriodiol® products as effective as top synthetic alternatives and far SUPERIOR to other natural repellents.

Citriodiol is natural, sustainable and ethical


Laboratory and field trials show complete protection against a variety of mosquito species for up to 8 hours (including Aedes, Anopheles, Culex, Ochlerotatus and Psorophora genera).


US EPA approved study (2019) demonstrates complete protection against deer tick, lone star tick and brown dog tick for up to 10 hours.

Other insects and arthropods

Provides protection from Midges, Flies (including Sand flies and Stable flies), Land Leeches and Head Lice.

We pride ourselves on providing comprehensive service and support.  Our technical, regulatory and product marketing experts can answer all your questions.

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