We have undertaken numerous field and laboratory trials to test the effect of Citriodiol® on an array of insects.

Citrefine Citriodiol backed by science

Leading authorities worldwide now recognise Citriodiol’s first-rate efficacy, making it the only plant-based repellent with this level of global accreditation. There is also a substantial body of data supporting its safety for use on human skin and in particular on young children and babies.

The toxicity profile of Citriodiol® extends to areas beyond acute toxicity assessment.  For example, it has no phototoxic potential, is non-mutagenic, passes the chromosome aberration test, is negative for inducing forward mutations at the TK locus in L5178Y mouse lymphoma cells, and is negative in the in-vivo mouse micronucleus assay. In longer-term sub chronic and chronic studies, it is shown to have no adverse reproductive or dermal developmental effect.  

In addition to the many toxicological studies done on Citriodiol® to ensure product safety for consumers, Citrefine has also conducted environmental testing to ensure that its products are not harmful to the environment. These tests have proven that Citriodiol® is rapidly biodegradable, so will not build up to potentially harmful levels in our soils and waterways, unlike many synthetic alternatives such as DEET. Because Citriodiol® is sourced from natural plant oil and is rapidly biodegradable it is also not toxic to birds, honey bees and other insects beneficial to the environment.

Phys/chem data including stability data is being generated on our product formulations where data gaps exist.  A validated method to extract and measure the amount of PMD has been successfully developed for these products and they have proved to be stable in 2-week accelerated stability testing at 54°C.  

We are keen to understand and promote the repellent properties of Citriodiol® so if you decide to conduct efficacy testing of your own, we would welcome the opportunity to review your results or even to comment on the proposed study protocol in advance.


Read summaries of our efficacy data and find links to other studies and reports


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